Notre Dame has suffered a few disappointing losses this season, but it has also shown that it can beat ranked teams. Notre Dame money line: Notre Dame +162, Clemson -195 Here are several college football odds for Clemson vs. You can head to SportsLine to see its picks. Now, the model has set its sights on Notre Dame vs. Anyone who has followed it has seen huge returns. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. The SportsLine Projection Model simulates every FBS college football game 10,000 times. Clemson picks, you'll want to see the college football predictions from the model at SportsLine. Notre Dame odds from Caesars Sportsbook, while the over/under for total points scored is 43.5. The Tigers are 4-point favorites in the latest Clemson vs. Notre Dame has scored 40-plus points in three of its last four wins, including a 41-point outburst at then-No. Clemson's biggest obstacle along its path to the CFP semifinals comes this weekend, as the Fighting Irish have won five of their last six games. 4 Clemson Tigers will try to remain positioned to make another appearance in the College Football Playoff when they face the Notre Dame Fighting Irish on Saturday night.
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